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Top 10 Heavily Shorted Small-Cap and Mid-Cap Stocks to Buy Today

by Global Market Bulletin
June 5, 2026
in Stock Market News
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Top 10 Heavily Shorted Small-Cap and Mid-Cap Stocks to Buy Today

Top 10 Heavily Shorted Small-Cap and Mid-Cap Stocks to Buy Today

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7. CRISPR Therapeutics AG (NASDAQ:CRSP)

Short Float: 30.48%
Market Cap: $5.23 Billion
Stock Upside Potential: 38.03%

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CRISPR Therapeutics AG (NASDAQ: CRSP) ranks No. 7 with a short float of 30.48%, a market capitalization of around $5.23 billion, and upside potential of 38.03%. The company develops transformative gene-based medicines using CRISPR/Cas9 gene-editing technology and remains one of the most important names in the gene editing stocks and biotech innovation space.

On May 27, Citizens reiterated a Market Perform rating and a $60 price target on CRISPR Therapeutics. The firm’s stance came as the company maintained a positive outlook on in vivo editing for cardiovascular disease. Clinical data presented at the European Atherosclerosis Society Congress continued to draw attention because gene-editing approaches may offer sustained lipid-lowering effects, a major potential breakthrough in cardiovascular medicine.

CRISPR Therapeutics is advancing a diversified portfolio of in vivo gene-editing programs using its proprietary liver-directed LNP delivery platform. CTX310, which targets ANGPTL3, is progressing in a Phase 1b clinical trial for severe hypertriglyceridemia and refractory hypercholesterolemia. The company is also working on CTX460 for alpha-1 antitrypsin deficiency and CTX340, which targets angiotensinogen for refractory hypertension. With 32 hedge fund holders, CRSP remains a heavily shorted biotech stock that still commands serious attention from institutional investors. For those searching for CRISPR stocks, gene-editing stocks, biotech stocks to buy now, and small-cap healthcare stocks with upside, CRSP continues to offer one of the more science-heavy setups on this list.

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Global Market Bulletin is a leading provider of stock market updates, economic news, and personalized investing guides. Our team brings you the latest global financial information to help you make smart investment decisions. About the Editorial Team Our editorial team consists of financial experts and seasoned market analysts who bring decades of experience to our coverage. With a commitment to unbiased reporting, our team ensures that every article is backed by thorough research and delivers accurate financial insights.

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